Calvin Pham
Frederick
Summary
Masters graduate with a degree in Medicinal chemistry, preparing to take on a new role in the Pharmaceuticals/ Biotech industry in the Spring of 2024. My goal is to contribute to the discovery and design of novel Biologics.
Overview
7
7
years of professional experience
Work History
Research Associate
Fredrick National Labatory
10.2024 - Current
- Purification of wide library of proteins
- Performed Microscale Purification for Protein Scouting
- Performed Large scale purification on FPLC
Conjugation Scientist
Rangam Consultants for Astrazeneca
08.2023 - 04.2024
- Executed Antibody-drug conjugate reduction, optimized and developed conjugation process
- Conducted post-conjugation chromatography purification process development and optimization
- TFF/UFDF process development
- Researched and presented internally on state-of-the-industry TFF processes for antibody-drug conjugates
Graduate Researcher (Dr.Heppner's Research Group)
State University of New York, University at Buffalo
08.2020 - 02.2023
- Conducted original research on drug design and optimization of protein kinase inhibitors
- Collected Synchrotron data for X-ray crystallography and experience with protein structure refinement (PDB ID's 7UKW & 7UKV)
- Contributed to experimental design by optimizing design of small molecule inhibitors and coordinated project directions with collaborators in Germany
- Biochemical and cellular characterization of novel tyrosine kinase inhibitors
- Experience using Alphafold for protein construct design and in vivo ligand docking for small molecules
- Experience mentoring post-baccalaureate students in experimental procedures and setting up new research lab and role as a lab safety officer
Organic Chemistry Lab Teaching Assistant
State University of New York, University at Buffalo
08.2020 - 12.2022
- Devised and presented lecture material on a weekly basis for over 60+ students
- Oversaw students safe technical execution of experiments in a wet lab setting
- Graded and provided feedback to student's coursework material
VCU Chemistry Dept. Research Assistant (Dr. Farrell's Research group)
Virginia Commonwealth University
05.2019 - 08.2020
- Synthesized biomimetic Zn-finger probes & Pt -based compounds used in anti-cancer applications
- Performed Fluorescence Quenching Assays for Pt compounds
VCU Psychology Dept. Research Assistant (Dr.Nao Hagiwara's Research Group)
Virginia Commonwealth University
08.2018 - 08.2020
- Organized community based outreach program to gather data about patient focused experience regarding healthcare disparities in the surrounding Richmond area
- Performed experiment coding and participated in weekly literature reviews
VCU Chemistry Dept. Stockroom Clerk
Virginia Commonwealth University
12.2017 - 05.2020
- Aided graduate students and faculty in sourcing materials and samples for research experiments
- Organized and managed communal resources as part of responsibilities of the department
Education
Master of Science - Medicinal Chemistry
SUNY University At Buffalo
Buffalo, NY02.2023
BS - Biochemistry, Psychology
Virginia Commonwealth University
Richmond, VA05.2020
Skills
- Assay Execution and Interpretation
- Biochemical and Cellular Assays
- Computer-aided Docking
- Structure Determination
- X-ray Crystallography
- Chemical Analysis
- Protein Analysis
- Setting up Crystal Trays
- Immunoassays
- Western Blotting
- SDS-PAGE
- Mentoring
- Teaching
- Chromatography (SEC)
- Affinity Chromatography (IEX, IMAC, ProA)
- Experience using an AKTA & NGC's
- Tangential Flow Filtration
- Experience working with ADC's
- Cell Culturing (Bacteria & Eukaryotic)
- Protein Purification
- Experience with Unicorn
- Experience with OpenLab
Patents
Benzodiazepinone-derived inhibitors of EGFR and HER2, Heppner, David, Laufer, Stefan, Wittlinger, Florian, Blessing, Ogboo, Pham, Calvin, Rasch, Alexander, 02/08/23
Publications
- Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors, Florian Wittlinger, Blessing C. Ogboo, Calvin D. Pham, Ilse K. Schaeffner, Surbhi Chitinis, Tahereh Damghani, Tyler S. Beyett, Alexander Rasch, Brian Buckley, Daniel Urul, Tatiana Shaurova, Earl May, Erik Schaefer, Michael J. Eck, Pamela A. Hershberger, Stefan A. Laufer, David E. Heppner, Submitted, 2023, https://chemrxiv.org/engage/chemrxiv/article-details/63e3b58c068fd759792faa80
- Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448), David E. Heppner, Florian Wittlinger, Tyler S. Beyett, Tatiana Shaurova, Daniel A. Urul, Brian Buckley, Calvin D. Pham, Ilse K. Schaeffner, Bo Yang, Blessing C. Ogboo, Earl W. May, Erik M. Schaefer, Michael J. Eck, Stefan A. Laufer, Pamela A. Hershberger, ACS Medicinal Chemistry Letters, 2022, 13, 12, 1856-1863
Presentations
- Jacobs School of Medicine: Protein Science Seminar, Structure-activity relationship of mutant-selective EGFR inhibitors that span the orthosteric and allosteric sites, Spring 2022
- SUNY Buffalo: Graduate Student Symposium, Targeting mutant EGFR with 'Two-in-one' ATP-allosteric hybrid inhibitors, Spring 2022
Timeline
Research Associate
Fredrick National Labatory
10.2024 - Current
Conjugation Scientist
Rangam Consultants for Astrazeneca
08.2023 - 04.2024
Graduate Researcher (Dr.Heppner's Research Group)
State University of New York, University at Buffalo
08.2020 - 02.2023
Organic Chemistry Lab Teaching Assistant
State University of New York, University at Buffalo
08.2020 - 12.2022
VCU Chemistry Dept. Research Assistant (Dr. Farrell's Research group)
Virginia Commonwealth University
05.2019 - 08.2020
VCU Psychology Dept. Research Assistant (Dr.Nao Hagiwara's Research Group)
Virginia Commonwealth University
08.2018 - 08.2020
VCU Chemistry Dept. Stockroom Clerk
Virginia Commonwealth University
12.2017 - 05.2020
BS - Biochemistry, Psychology
Virginia Commonwealth University
Master of Science - Medicinal Chemistry
SUNY University At Buffalo
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