Timur Gaynutdinov

Principal Scientist with 10+ years of experience in downstream process development for viral vectors and biologics, with deep expertise in lentiviral vector (LVV) purification for cell and gene therapy applications. Proven track record of building scalable, phase-appropriate DSP platforms supporting early discovery through IND-enabling development. Experienced in leading cross-functional programs spanning process development, analytical development, manufacturing, and CMC to deliver robust purification processes, accelerate development timelines, and reduce reliance on external CDMOs. Expertise includes clarification, chromatography, UF/DF (TFF), sterile filtration, DOE/QbD-driven optimization, in-process monitoring, and analytical integration for viral vector manufacturing.

• 1. Scribner JA, Brown JG, Son T, Chiechi M, Li P, Sharma S, Li H, De Costa A, Li Y, Chen Y, Easton A, Yee-Toy NC, Chen FZ, Gorlato S, Barat B, Huang L, Wolff CR, Hooley J, Hotaling TE, Gaynutdinov T, Ciccarone V, Tamura J, Koenig S, Moore PA, Bonvini E, Loo D. Mol Cancer Ther. Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer., Sep 23 2020
• 2. Gaynutdinov T.I., Englund E.A., Appella D.H., Onyschenko M.I., Neumann R.D. and Panyutin I.G. Nucl. Acids Ter. G-quadruplex formation between G-rich PNA and homologous sequences in oligonucleotides and supercoiled plasmid DNA. V. 25(2), 78-84. 2015
• 3. Onyschenko M.I., Gaynutdinov T.I., Englund E.A., Appella D.H., Neumann R.D. and Panyutin I.G. Nucl. Acids Res. Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region. Acids Res., V. 39(16), 7114-7123. 2011
• 4. Gaynutdinov T.I., Neumann R.D. and Panyutin I.G. Assessing DNA Structures with 125I Radioprobing. In “G-Quadruplex DNA Methods and Protocols”, Series: Methods in Molecular Biology, (Ed. P. Baumann); Springer, V. 608, 137-145, 2010
• 5. Gaynutdinov T.I., Brown P.H., Neumann R.D. and Panyutin I.G. Duplex Formation at the 5' end Affects Quadruplex Conformation of the Human Telomeric Repeat Overhang in Sodium but not in Potassium. Biochemistry, V. 48, 11169-11177, 2009
• 6. Onyschenko M.I., Gaynutdinov T.I., Englund E.A., Appella D.H., Neumann R.D. and Panyutin I.G. Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs. Nucleic Acids Res., V. 31(22), 7570-7580. 2003
• 7. Gaynutdinov T.I., Neumann R.D. and Panyutin I.G. Iodine-125 Radioprobing of Intramolecular Quadruplex Conformation of Human Telomeric DNA in the Presence of Cationic Porphyrin TMPyP4. Int. J. of Radiat. Biol., V. 84, 984-990, 2008
• 8. Gaynutdinov T.I., Neumann R.D. and Panyutin I.G. Structural Polymorphism of Intramolecular Quadruplex of Human Telomeric DNA; Effect of Cations, Quadruplex Binding Drugs and Flanking Sequences. Nucl. Acids Res., V. 36, 4079-4087, 2008
• 9. Backer M.V., Gaynutdinov T.I., Patel V., Bandyopadhyay A., Thirumamagal B.T., Tjarks W., Barth R.F., Claffey K., Backer J.M. Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature. Mol. Cancer Ther. V. 4(9), 1423-1429, 2005
• 10. Gaynutdinov T.I., Myshkin E., Backer J.M., Backer M.V. Chimeric ribonuclease as a source of human angiostatin protein for targeted drug delivery. Protein Eng. V. 16, No. 10, 771-775, 2003
• 11. Backer M.V., Gaynutdinov T.I., Gorshkova I.I., Crouch R.J., Hu T., Aloise R., Arab M., Przekop K., Backer J.M. Humanized docking system for assembly of targeting drug delivery complexes. J. Control Release V. 89, No. 3, 499-511, 2003
• 12. Backer M.V., Gaynutdinov T.I., Aloise R., Przekop K., Backer J.M. Engineering S-protein fragments of bovine ribonuclease A for targeted drug delivery. Protein Expr. Purif. V. 26, No. 3, 455-461, 2002
• 13. Gaynutdinov T.I., Shestova O.E., Yakubov L.A., Dobrikov M.I., Vlassov V.V. Sensitized photomodification of oligonucleotide-binding proteins displayed on the eucaryotic cell surface. Russ. Chem. B+ V. 51, No. 7, 1198-1203, 2002
• 14. Dobrikov M.I, Gainutdinov T.I., Ivanova T.M., Vlassov V.V. Sensitized Site-specific Photomodification of ssDNA by Binary Systems of Oligonucleotide Conjugates: VI. Effect of Substituents in the Sensitizer Anthracene Residue. Russian J. Bioorgan. Chem. V. 26, No. 8, 553-559, 2000
• 15. Dobrikov M.I., Gaidamakov S.A., Gainutdinov T.I., Vlassov V.V. Sensitized DNA Photomodification of DNA by Binary Systems of Oligonucleotide Conjugates: V. The Target DNA Sequence Effect and the Quantitative Photomodification. Russian J. Bioorgan. Chem. V. 25, No. 2, 118-126, 1999
• 16. Dobrikov M.I., Bichenkova E.V., Douglas K.T., Gainutdinov T.I., Vlassov V.V. Structure of Photoreactive Binary System of Oligonucleotide Conjugates Assembled on the Target Nucleotide Sequence. J. Biomol. Struct. Dynamics, V. 17, No. 2, 213-221, 1999
• 17. Dobrikov M. I., Gainutdinov T. I., Vlassov V. V. Visible Light Activatable Binary System of Oligonucleotide Conjugates for Nucleic Acids Modification. Nucleosides Nucleotides V. 18, No. 6-7, 1517-1518, 1999
• 18. Dobrikov M.I., Gaidamakov S.A., Gainutdinov T.I., Tenetova E.D., Shishkin G.V., Vlassov V.V. Sensitized DNA Photomodification of DNA by Binary Systems of Oligonucleotide Conjugates. IV. Photoinduced Electron Transfer. Russian J. Bioorgan. Chem. V. 25, No. 1, 26-33, 1999
• 19. Dobrikov M.I., Gaidamakov S.A., Gainutdinov T.I., Tenetova E.D., Shishkin G.V., Vlassov V.V. The Binary System of Oligonucleotide Derivatives of the Perylene and n-Azidotetrafluoro-benzalhydrazone for Sensitized to Visible Light DNA Photomodification. Dokl Acad Nauk, V. 358, No. 3, 403-407, 1998
• 20. Dobrikov M.I., Gaidamakov S.A., Gainutdinov T.I., Koshkin A.A., Lukyanchuk N.P., Shishkin G.V., Vlassov V.V. Sensitized DNA Photomodification by Binary Systems. I. Synthesis of Oligonucleotide Conjugates and Influence of Their Composition on the Efficiency of Target Modification. Russian J. Bioorgan. Chem. V. 23, No. 3, 171-178, 1997
• 21. Dobrikov M.I., Gaidamakov S.A., Gainutdinov T.I., Koshkin A.A., Vlassov V.V. Sensitized Photomodification of ssDNA by a Binary System of Oligonucleotide Conjugates. Antisense Nucl. Acid Drug. Develop. V. 7, 309-317, 1997
• 22. Vlassov V.V., Gaidamakov S.A., Gainutdinov T.I., Koshkin A.A., Dobrikov M.I. Binary Systems of Oligonucleotide Conjugates for Sequence Specific Energy-Transfer Sensitized Photomodification of Nucleic Acids. In “DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases”. (Ed. D. Meunier); Dordrecht: Kluwer Academ. Publ. V. 479, 195-210, 1996